Excessive cell growth causes cytoplasm dilution and contributes to senescence

Gabriel E Neurohr, Rachel L Terry, Jette Lengefeld, Megan Bonney, Gregory P Brittingham, Fabien Moretto, Teemu P Miettinen, Laura Pontano Vaites, Luis M Soares, Joao A Paulo, J Wade Harper, Stephen Buratowski, Scott Manalis, Folkert J Van Werven, Liam J Holt & Angelika Amon
Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size is important remains poorly understood. Here we show that growing budding yeast and primary mammalian cells beyond a certain size impairs gene induction, cell-cycle progression, and cell signaling. These defects are due to the inability of large cells to scale nucleic acid and protein biosynthesis in...
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