Elucidating the Role of Complement Activation in the Pathogenesis of Alpha-1 Antitrypsin Deficiency

Laura Fee
Alpha-1 antitrypsin deficiency (AATD) is characterised by low circulating levels of alpha-1 antitrypsin (AAT) and is associated with neutrophil-driven chronic obstructive pulmonary disease (COPD), liver disease and other autoimmune comorbidities including vasculitis and panniculitis. Complement C3 has recently been identified as a binding partner of AAT. The aim of this study was to evaluate the significance of the lack of this binding event in AATD. A significant link between AATD manifestations and those which are...
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