The role of α2 agonists in paediatric critical care sedation

John Hayden
Background There are two α2 agonists used in sedation in paediatric critical care in Ireland. Firstly, the older medication clonidine and secondly the newer, more selective, α2 agonist dexmedetomidine. Neither agent is licensed for use in paediatrics despite both being in routine clinical use. Not being licensed in children has meant both medications bypassed formal efficacy and safety studies in children during their development. This thesis aimed to address current knowledge deficits and provide an...
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