Metabolic Reprogramming of the Cystic Fibrosis Neutrophil

Oliver J. McElvaney
Cystic fibrosis (CF) is the commonest lethal genetic condition affecting Caucasians, arising from a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene on the long arm of chromosome 7. It is a chloride channelopathy, manifesting clinically as a multisystem disorder. The major cause of morbidity and mortality in CF is neutrophilic lung disease, though significant debate exists as to whether the main determinant of this is an intrinsic defect due to defective CFTR...
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