In vivo and in vitro degradation of tissue engineered collagen and mineralised collagen scaffolds used in bone tissue engineering

Stephen M. Kieran
A clinical need exists to provide alternatives to autologous bone grafting for the reconstruction of head and neck bone defects. This thesis examines the utility and success of a tissue engineering approach to this problem using novel collagen based scaffolds combined with mesenchymal stem cells. The objective of this work was to determine how the addition of a calcium phosphate mineral phase to a collagen-based scaffold, designed for use in bone tissue engineering, affects the...
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