Investigating the immune response to Staphylococcus aureus bloodstream infection in haemodialysis patients

Roisin Connolly
Staphylococcus aureus bloodstream infection (SA-BSI) is a serious and potentially fatal problem in haemodialysis patients. An effective S. aureus vaccine would have significant benefits in this group. Previous antibody-inducing vaccine candidates failed to prevent or attenuate SA-BSI and it is now accepted that next-generation anti- S. aureus vaccines must also induce effective T-cell-mediated immunity. Recent advances have helped to elucidate the role of specific T-cell subsets, notably Th1 and Th17 cells, which coordinate an effective...
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