Caecal dysfunction and neuro-immune alterations in a preclinical model of autism

Chalystha Yie Qin Lee, Gayathri K Balasuriya, Madushani Herath, Ashley Franks & Elisa Hill-Yardin
Autism Spectrum Disorder (ASD; autism) is commonly presented with gastrointestinal (GI) illness in addition to core diagnostic behavioural traits. Important for GI homeostasis is the appendix, or the caecum in mice, which functions as a key site for fermentation and a microbial reservoir. Even so, the role of the appendix and caecum in autism-associated GI symptoms remains uninvestigated. Here, we studied mice with an autism-associated missense mutation in the post-synaptic protein neuroligin-3 (NL3R451C), which impacts...
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