Cellular Mechanism of Reactivation of Lytic Cycle of Epstein-Barr Virus (EBV) by a Novel Compound, C7, in EBV-associated Epithelial Malignancies

Pei Tung Stephanie Yiu
Pharmaceutical reactivation of lytic cycle of Epstein–Barr virus (EBV) represents a potential therapeutic strategy against EBV-associated epithelial malignancies, e.g., gastric carcinoma (GC) and nasopharyngeal carcinoma (NPC). A novel lytic-inducing compound, C7, which exhibits structural similarity to Di-2-Pyridyl Ketone 4, 4-Dimethyl-3-Thiosemicarbazone (Dp44mT), a known chelator of intracellular iron, is found to reactivate EBV lytic cycle in GC and NPC. This study aims to delineate the mode of action of C7 and clinically available iron chelators in...
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