Hepatocellular carcinoma (HCC) is one of the deadliest cancers across the globe. Patients are usually diagnosed at advanced stage. Presence of microvascular metastasis, oversized tumor burden and insufficient liver remnant reduce the feasibility to surgical and local ablative treatment modalities. Besides, high propensity of tumor recurrence and metastasis increase the level of challenge in eliminating HCC. As a matter of fact, targeted therapy confers survival benefits to HCC patients in late phase. In this regard,...