Avian influenza virus as an oncolytic therapy for pancreatic cancer

Matteo Samuele Pizzuto
Pancreatic ductal adenocarcinoma (PDA) is one of the leading causes of cancer-related deaths worldwide and the development of new treatment strategies for patients suffering from PDA is of crucial importance. Virotherapy uses natural or engineered oncolytic viruses (OVs) to selectively kill tumour cells. Although various OVs are being investigated as agents for pancreatic cancer treatment, due to the genetic heterogeneity of PDA cells and their consequent mixed permissiveness to viruses, virotherapy should not rely on...
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