The role of miRNA deregulation in non-genotoxic chemical induced carcinogenesis

Mariana Flores Torres
MicroRNAs (miRNAs) are short, non-protein coding RNAs. These small-RNAs can regulate gene expression by either inhibiting translation or promoting mRNA degradation, they are also involved in diverse physiological and pathological events. Previous data from our group, showed that phenobarbital (PB, a CAR activator), induces dysregulation of the hepatic miRNAome in rat livers. In this study, we aim to determine if non-genotoxic rodent carcinogens can deregulate miRNA expression. Thus, the liver miRNAome associated with a novel...
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