Identification of unique genetic and epigenetic signatures in myeloproliferative neoplasms using microarray and next generation sequencing: association with MPN-related mutations and clinical phenotypes

Chieh Lee Wong
The past decade has witnessed significant progress in the understanding of the molecular pathogenesis of myeloproliferative neoplasms (MPN). Mutations in a large number of genes have now been implicated in the pathogenesis of MPN but their relative importance, the mechanisms by which they cause different cells to predominate and differentiate into the separate MPN syndromes and their implications for prognosis remain unknown. I hypothesized that other genes and epigenetic mechanisms may contribute to the pathogenesis...
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