Investigation into the glycosylation mechanism of polyglycerolphosphate lipoteichoic acid in firmicutes

Matthew G Percy
Lipoteichoic acid (LTA) constitutes a major component of the cell wall in Gram-positive bacteria belonging to the phylum Firmicutes. The chemical structure of LTA varies between different bacteria. Type I LTA, a polyglycerolphosphate polymer often further decorated with D-alanine and glycosyl moieties, is linked to the outside of the membrane via a glycolipid anchor, and is one of the most common and best characterized structures. While the D-alanyl modification is known to protect bacteria against...
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