Genetic and cellular mechanisms of autoimmunity in lupus-prone B6.129-Sle16 mice

Norzawani Binti Buang
Genome sequencing and transcriptomic analyses are hypothesis-free approaches to identify genetic variants(s) and biological pathway(s) associated with a disease. T cells are paramount in the pathogenesis of systemic lupus erythematosus (SLE). Hyperactive CD4+ T cells can promote the production of auto-antibodies by offering excessive help to B cells. B6 congenic mice carrying the Sle16 locus (B6.129-Sle16) have increased auto-antibody levels, mild glomerulonephritis, and hyperactive T and B cells. These data indicate that intrinsic T cell...
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