Solvent effects on an SNAr reaction; mechanism, kinetics, solvent design

Eliana Harriet Grant
This work provides a detailed study of an example SNAr reaction as these transformations are widely used in the synthesis of pharmaceutical drugs. The specific reaction we are considering is that of 2,4-difluoroacetophenone and pyrrolidine which has not previously been reported in the literature. We focus on elucidating the effect of solvent on the reaction mechanism and kinetics with a subsequent solvent design study to optimise both the reaction rate constant and selectivity. The solvent...
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