Characterisation of chamber-specific fibroblasts from adult human heart and investigation of their potential contribution to the function of engineered heart tissue

Amina Khalil
Research in the past 15 years has shown that the adult heart, including human, contains cardiac fibroblasts exhibiting regenerative capacity. Little is known about the precise characteristics, properties, and differentiation potential of endogenous cardiac fibroblasts (CF) in the four cardiac chambers of the human heart, and how these are affected by the disease process. The fibroblast population in the heart is being redefined from an inert scar-forming cell type into one, which has an active...
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