The impact of human immunodeficiency virus-1 viral replicative capacity on infection of human cervical and rectal tissue explants ex vivo

Robert Kipyegon Langat
Characterization of the targets and kinetics of HIV infection within rectal and genital tissues is central to the assessment of novel prevention agents. The ex vivo models available are helpful for studying the initial stages of HIV‐1 infection, such as defining the primary HIV target cells and the factors that influence viral replication kinetics. Five HIV-1 clade C, 1 clade A and 1 clade A/D HIV-1 TF variants were isolated from IAVI Protocol C; a...
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