Synthesis of macrocycles via olefin metathesis: process intensification using organic solvent nanofiltration

Anna Cupani
Macrocycles are an important feature of many pharmaceutical compounds. They combine high target selectivity and lower metabolic degradation than acyclic analogues but are difficult to synthesise and mostly extracted from natural sources. With the discovery of olefin metathesis reaction, cycles of different sizes can now be obtained efficiently via Ring Closing Metathesis (RCM). To avoid side-product formation, the cyclization is done in extremely diluted conditions. This approach requires large amounts of solvents, is expensive and...
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