Cryo-EM studies of CMG translocation and cohesin loading

Carl Patrik Eickhoff
Before mitosis, the genome must be replicated in the parental cell and sister chromatids must be tethered to ensure accurate division of genes between daughter cells. Within the replisome, DNA unwinding is facilitated by the CMG helicase which contains a hexameric ATPase motor encircling the leading strand template. Intriguingly, the helicase polarity, the mechanism of translocation and how CMG- bound replisome factors such as Mcm10, the MCT complex and PolĪµ affect the helicase has remained...
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