The distribution and characteristics of endogenous cardiac stem cells in the adult human heart

Sajiram Sarvananthan
The human myocardium harbours resident multi-potent cardiac progenitor cells (CPCs). We investigated the distribution, properties, differentiation potential and effect of LV function on CPCs in all chambers of the human heart. Biopsies from all chambers of the heart from the same patient with good (EF>45; n=5) and impaired LV function (EF<45; n=5) was analysed for c-kitpos and MDR-1pos CPCs. CPCs were isolated using MACS from ten patients (Good and Impaired LV, n=5/group) and was characterised....
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