Targeting cell mechanics to inhibit metastatic mechanisms in pancreatic cancer

Alistair Rice
Metastasis, the spread of cancer cells from the primary tumour to a secondary site, requires biochemical and physical changes in cellular behaviour that are influenced by the tumour microenvironment. In pancreatic ductal adenocarcinoma (PDAC), excessive deposition of extracellular matrix proteins leading to increased stiffness characteristically occurs with cancer development, and the fibrotic stroma produced promotes tumourigenesis. Many cellular behaviours, for example the epithelial-mesenchymal transition (EMT), chemoresistance and invasiveness, are associated with increased levels of metastasis....
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