Characterising the bidirectional biomolecular interactions between the intestinal microbiota and host drug metabolism

Marine Patricia Magali Letertre
In pharmacological and toxicological studies, the aim is to improve drug efficacy while limiting toxicity. It is now recognised that the gut microbiota, which constitutes trillions of microbial cells and contains 150 time more genes that the human genome itself, can synthesise enzymes and metabolites that can influence the metabolism and toxicity of drugs in the host. Conversely, drugs themselves have also been identified to exert an impact on the community structure of the gut...
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