Imaging Molecular Recognition by the Inhibitory Human Natural Killer Cell Receptor KIR2DL1

Sophie Victoria Pageon
Natural Killer (NK) cells are lymphocytes that identify and kill virus-infected and tumour cells dependent on recognition via numerous activating and inhibitory surface receptors. The mechanisms by which NK cells can integrate activating and inhibitory signals at the immune synapse remain unclear, although a correlation has been established between a cell’s response and the organisation of receptors into specific molecular patterns at the synapse. Here, I used three novel imaging techniques to investigate the spatial...
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