Testing a sustainable source of Taxol for the treatment of RUNX cancers using Caenorhabditis elegans

David Van De Klashors & Samantha Hughes
RUNX proteins, master regulators of development, are frequently dysregulated in cancers, particularly leukaemia and breast cancer. A common drug for RUNX cancers, Paclitaxel, is derived from the bark of the Taxus plant. We tested compounds derived from leaves and needles of Taxus as a sustainable source of compounds to treat RUNX cancers. We accessed the effectiveness of Paclitaxel, Cephalomannine and 10-Deacetylbacatin III (10-DAB), in a Caenorhabditis elegans RUNX cancer model. Our results show Taxol derivatives...
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