Testing a sustainable source of Taxol for the treatment of RUNX cancers using Caenorhabditis elegans

David Van De Klashors & Samantha Hughes
RUNX proteins, master regulators of development, are frequently dysregulated in cancers, particularly leukaemia and breast cancer. A common drug for RUNX cancers, Paclitaxel, is derived from the bark of the Taxus plant. We tested compounds derived from leaves and needles of Taxus as a sustainable source of compounds to treat RUNX cancers. We accessed the effectiveness of Paclitaxel, Cephalomannine and 10-Deacetylbacatin III (10-DAB), in a Caenorhabditis elegans RUNX cancer model. Our results show Taxol derivatives...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.