High prevalence and diversity of species D adenoviruses (HAdV-D) in human populations of four Sub-Saharan countries

Maude Pauly, Eileen Hoppe, Lawrence Mugisha, Klara Petrzelkova, Chantal Akoua-Koffi, Emmanuel Couacy-Hymann, Augustin Etile Anoh, Arsène Mossoun, Grit Schubert, Lidewij Wiersma, Sabwe Pascale, Jean-Jacques Muyembe, Stomy Karhemere, Sabrina Weiss, Siv Aina Leendertz, Sébastien Calvignac-Spencer, Fabian Leendertz & Bernhard Ehlers
Background: Human adenoviruses of species D (HAdV-D) can be associated with acute respiratory illness, epidemic keratoconjunctivitis, and gastroenteritis, but subclinical HAdV-D infections with prolonged shedding have also been observed, particularly in immunocompromised hosts. To expand knowledge on HAdV-D in Sub-Saharan Africa, we investigated the prevalence, epidemiology and pathogenic potential of HAdV-D in humans from rural areas of 4 Sub-Saharan countries, Côte d’Ivoire (CI), Democratic Republic of the Congo (DRC), Central African Republic (CAR) and Uganda...
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