Changes to cholesterol trafficking in macrophages by Leishmania parasites infection

Geo Semini, Daniel Paape, Athina Paterou, Juliane Schroeder, Martin Barrios-Llerena & Toni Aebischer
Leishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases. It has been demonstrated that host cholesterol plays an important role during Leishmania infection. Nevertheless, little is known about the intracellular distribution of this lipid early after internalization of the parasite. Here, pulse-chase experiments with radiolabeled cholesteryl esterified to fatty acids bound to low-density lipoproteins indicated that retention of this...
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