Population Genomics of Francisella tularensis subsp. holarctica and its Implication on the Eco-Epidemiology of Tularemia in Switzerland

Matthias Wittwer, Ekkehard Altpeter, Paola Pilo, Sebastian M. Gygli, Christian Beuret, Frederic Foucault, Rahel Ackermann-Gäumann, Urs Karrer, Daniela Jacob, Roland Grunow & Nadia Schürch
Whole genome sequencing (WGS) methods provide new possibilities in the field of molecular epidemiology. This is particularly true for monomorphic organisms where the discriminatory power of traditional methods (e.g., restriction enzyme length polymorphism typing, multi locus sequence typing etc.) is inadequate to elucidate complex disease transmission patterns, as well as resolving the phylogeny at high resolution on a micro-geographic scale. In this study, we present insights into the population structure of Francisella tularensis subsp. holarctica,...
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