Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398

Tobias Busche, Mélanie Hillion, Vu Van Loi, David Berg, Birgit Walther, Torsten Semmler, Birgit Strommenger, Wolfgang Witte, Christiane Cuny, Alexander Mellmann, Mark A. Holmes, Jörn Kalinowski, Lorenz Adrian, Jörg Bernhardt & Haike Antelmann
The spread of methicillin-resistant Staphylococcus aureus (MRSA) in the community, hospitals and in livestock is mediated by highly diverse virulence factors that include secreted toxins, superantigens, enzymes and surface-associated adhesins allowing host adaptation and colonization. Here, we combined proteogenomics, secretome and phenotype analyses to compare the secreted virulence factors in selected S. aureus isolates of the dominant human- and livestock-associated genetic lineages CC8, CC22, and CC398. The proteogenomic comparison revealed 2181 core genes and 1306...
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