Polylactide coated hydroxyapatite nanoparticles for reinforced biodegradable polymer scaffolds

Melissa Pasli, Patrizia Smith & Stephen Boyes
Tissue engineering involves combining cells and biomaterials to generate scaffolds that act as templates for tissue regeneration. Polylactide (PLA) is a biocompatible and biodegradable polymer, but critical problems are associated with it due to its hydrophobicity and its inadequate mechanical properties. Hydroxyapatite (HA) nanoparticles (Ca10(PO4)6(OH)2) exhibit chemical similarity to the main mineral component of bone, and promise to provide strength to compensate for the low durability of PLA. Due to the incompatibility of unmodified hydroxyapatite...
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