Nanoimmunoassays for malaria diagnosis

Inês Gomes, Ana Reis, Eulália Pereira, Elvira Fortunato, Miguel Prudêncio & Ricardo Franco
The development of Rapid Diagnostic Tests (RDTs) for malaria diagnosis is an area of intense research. Here, we describe two nanoimmunoassays for malaria parasite detection; one based on agarose gel electrophoresis; and another employing lab-onpaper technology. Both nanoimmunoassays use gold nanoparticles (AuNPs) functionalized with 11-mercaptoundecanoic acid (MUA) or with the pentapeptide CALNN, and further conjugated with a monoclonal antibody (anti- PfHRP2) that specifically recognizes Plasmodium falciparum Histidine Rich Protein 2 (PfHRP2) antigen. The formation of...
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