The Endogenous Protein Degradation System zif-1/ZF1 as a Selection Scheme for miniMos Insertions in Caenorhabditis elegans

Yasmine Soqrat
miniMos is a technique to generate random DNA insertions in C. elegans based on the Mos1 transposon. Transposition can be used in forward genetic screens to identify novel genes and regulatory elements. However, it has been challenging to develop protocols to generate the many miniMos insertions that are necessary for comprehensive genetic screens. One main challenge is to distinguish positive selection conferred by miniMos elements in multi-copy extra-chromosomal arrays, an intermediary step, from selection conferred...
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