Chemoenzymatic and fully stereocontrolled total syntheses of the antibacterial natural product (-)-platencin and an analogue

Ee Ling Chang
The rise of antibiotic-resistant bacteria represents a growing crisis that threatens global security and the world economy. The natural product platencin has recently been identified as a potent antibacterial agent with a novel mode of action. As such, it is an important lead in the development of next-generation antibacterials that are urgently needed because of the rapidly developing resistance to current therapies. The work detailed in this thesis exploits previous research carried out within the...
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