Identification of pathways involved in breast cancer susceptibility - contribution of SuprMam loci

Madara Ratnadiwakara
Two genomic regions that modify mammary, SuprMam1 and SuprMam2 have been identified in the BALB/c mouse strain in the Trp53+/- mouse model. We studied mammary gland morphology, tumour growth and expression levels of potential candidate genes and pathways in SM09 congenic mice (BALB/c SuprMam loci in C57BL/6 background) in comparison to parental strains, to identify the genes within the SuprMam loci that might be responsible for higher breast cancer susceptibility in BALB/c mice. While the...
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