Novel role for heparan sulfate in thymic development of CD8⁺ T lymphocytes

David Anak Simon Davis
The thymic stromal microenvironment is crucial for MHC-restricted positive and negative selection of T cells in the thymus to generate functional and self-tolerant alphabeta T cells. Our recent studies have provided new insights into this important process. We found that CD8beta molecules on CD4+CD8+ double positive (DP) thymocytes strongly interact with highly sulfated heparan sulfate (HS) carrying 6-O sulfate groups. Furthermore, we discovered that a HS mimetic (dextran sulfate 500-kDa) can trigger a sustained Ca2+...
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