The contribution of genetic variation to development of systemic lupus erythematosus

Simon Hee-Tang Jiang
Systemic lupus erythematosus is the prototypical autoimmune disease characterised by multi-organ involvement. Genetic variance is one of the most potent risk factors for development of lupus yet currently identified variants only account for 15% of genetic risk. Despite a strong genetic basis it does not follow Mendelian patterns of inheritance. A favoured hypothesis is that many common, mildly damaging variants combine to predispose to lupus. An alternative hypothesis is that few rare damaging variants cause...
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