Specific binding of exogenous sex hormones and chemical substances to sex hormone-binding globulin (SHBG) in carp and rainbow trout

Masaki Nagae, Yuichi Suminami, Hiroko Kitagawa, Ken Ichirou Shiroyama, Nobuyuki Ohkubo & Takahiro Matsubara
The binding characteristics of sex hormone-binding globulin (SHBG ), the most important transporter of sex steroids in blood, was investigated using various kinds of sex steroids in carp and rainbow trout in vivo and in vitro. In vitro binding assay using various kinds of sex steroids revealed androgens (T and 11-KT), estrogens (E2 and EE2) and progestins (17α-P and 17α,20b-DP) have a high affinity to SHBG. However, the affinity of estrone, cortisol, and bisphenol-A to...
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