Dysregulated Gene Expression in Lymphoblasts from Parkinson’s Disease

Sarah Annesley, Claire Allan, Oana Sanislav, Andrew Evans & Paul Fisher
Parkinson’s disease is the second largest neurodegenerative disease worldwide and is caused by a combination of genetics and environment. It is characterized by the death of neurons in the substantia nigra of the brain but is not solely a disease of the brain, as it affects multiple tissues and organs. Studying Parkinson’s disease in accessible tissues such as skin and blood has increased our understanding of the disease’s pathogenesis. Here, we used lymphoblast cell lines...
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