Phylogenetic Classification and Functional Review of Autotransporters

Kaitlin Clarke, Li Lian Hor, A Pilapitiya, J Luirink, Jason Paxman & Begona Heras
Autotransporters are the core component of a molecular nano-machine that delivers cargo proteins across the outer membrane of Gram-negative bacteria. Part of the type V secretion system, this large family of proteins play a central role in controlling bacterial interactions with their environment by promoting adhesion to surfaces, biofilm formation, host colonization and invasion as well as cytotoxicity and immunomodulation. As such, autotransporters are key facilitators of fitness and pathogenesis and enable co-operation or competition...
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