Investigating the neuroprotective capabilities of glial-derived neurotrophic factor following intraluminal filament middle cerebral artery occlusion in mice

Gary Morris
Therapeutic drug development for stroke has been hampered by the consistent clinical failure of promising preclinical candidate neuroprotectants. In this study we adopted the use of one of the most common preclinical models of stroke, intraluminal filament middle cerebral artery occlusion (MCAO). Despite being widely used it is plagued by inconsistency, owing in part to the multitude of variables requiring control. This thesis had two major aims; 1. The establishment of a reproducible intraluminal MCAO...
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