Synthesis of Novel Fused-Ring Flavonoid Systems and Their Anticancer Activity

Vidia Afina Nuraini
This project aimed to synthesize fused-ring systems derived from flavanones and isoflavanones by utilizing the chemistry of the highly reactive ortho-quinone methide (o-QM) intermediate. The synthesis of cis-4-arylisoflavan and isoflavene derivatives was also explored by employing different metal catalysts. The fused-ring systems were synthesized via inverse electron-demand Diels Alder (iEDDA) reaction between dienophiles and o-QM intermediate, which was generated in situ by thermolysis of the corresponding Mannich base. The reaction proceeded in a highly regioselective...
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