Bacillus Calmette-Guérin vaccination against bovine tuberculosis: Is Perfect the Enemy of Good?

S. Srinivasan, V. Kapur, A. Conlan, L. Easterling, C. Herrera, P. Dandapat, M. Veerasami, G. Ameni, N. Jindal, J. Wood, N. Juleff, D. Bakker & K. Vordermeier
More than 50 million cattle are likely exposed to bovine tuberculosis (bTB) worldwide, highlighting a need for vaccination in regions where bTB is endemic and test-and-slaughter approaches are unfeasible. Bacillus Calmette-Guérin (BCG) was first evaluated as a vaccine in cattle even before its widespread use in humans, yet its efficacy in cattle remains poorly understood. We performed a systematic review and meta-analysis on the efficacy of BCG against bTB challenge in cattle, which demonstrated a...
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