Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5

S. Frese, M. Frese-Schaper, A. C. Andres, D. Miescher, B. Zumkehr & R. A. Schmid
Tumor necrosis factor (TNF)-related apoptosisincluding ligand (Apo2L/TRAIL) belongs to the TNF family known to transduce their death signals via cell membrane receptors. Because it has been shown that Apo2L/TRAIL induces apoptosis in tumor cells without or little toxicity to normal cells,[for full text, please go to the a.m. URL]