A causal role of C-reactive protein (CRP) in inflammation: Conformational rearrangement in CRP is required for enhanced pro-inflammatory leukocyte activation and leukocyte adhesion in ischemia-reperfusion of the striated muscle

S. U. Eisenhardt, A. Murphy, K.J. Woollard, A. Bobik, J. Chin-Dusting, K. Peter & G.B. Stark
Introduction: C-reactive protein (CRP) is the prototypic acute phase reactant and consists of 5 identical non-covalently linked subunits. Recently it has been proposed that CRP is not only a marker, but also a mediator of inflammatory processes. Here we investigated the pathogenetic role of CRP in ischemia-reperfusion[for full text, please go to the a.m. URL]