Influence of sedatives and analgesics on spreading depolarisations in brain injured patients

O. Sakowitz, D. Hertle, D. Haux, B. Orakcioglu, K. Kiening & A. Unterberg
Objective: Spreading depolarisations (SD), characterized by large propagating slow potential changes, have been demonstrated in patients with brain injury using electrocorticography (EcoG). SDs occur early after brain injury while most patients are under sedation and analgesia. The influence of sedatives[for full text, please go to the a.m. URL]