Plasminogen activator inhibitor one decreases tissue plasminogen activator induced delayed edema in an experimental porcine intracranial hemorrhage model

N. Uzma, U. Samadani, G. Meier, K. Kallenberg, P. Dechent, W. Brueck & V. Rohde
Objective: Hematoma puncture and clot lysis emerged as an alternative therapy for intracerebral hemorrhages (ICH). Recently, an international multicenter study (MISTIE trial) has been initated. However, we have shown in an animal study that recombinant tissue plasminogen activator (rtPA) to lyse ICHs[for full text, please go to the a.m. URL]