After ventricular hemorrhage the ATP-sensitive PY2-receptor induces a Ca2+-rise in the cytosol resulting in necrosis but not apoptosis in human astrocytes

W. Scharbrodt, Y. Abdallah, S. Kasseckert, H. Piper, D.-K. Böker, M. Stein, M. Miqdad & M. Oertel
Objective: Ca2+-is a cofactor of many cellular processes including apoptosis and necrosis. This study’s hypothesis was that bloody CSF from patients after intraventricular hemorrhage may cause a Ca2+-rise which induces apoptosis or necrosis in an in-vitro model of human cerebral astrocytes.[for full text, please go to the a.m. URL]