Leukotriene synthesis inhibitors attenuate posttraumatic lesion size, CSF leukotriene levels and pericontusional inflammatory reaction in a brain contusion model

C. Voigt, W. Härtig, C. Donat, A. Wetterholm, M. Skardelly & M. Schuhmann
Objective: To test the hypothesis that leukotrienes are involved in the process of increasing contusion size and brain edema development, we investigated the effect of MK-886, an inhibitor of 5-lipoxygenase (5-LO) synthesis and of Boscari, a competitive non-redox 5-LO inhibitor. Methods: 92 SD rats[for full text, please go to the a.m. URL]