MGMT methylation status remains unchanged in recurrent malignant gliomas after radio-/chemotherapy

N. Thon, S. Eigenbrod, J.-C. Tonn & F.-W. Kreth
Objective: Epigenetic silencing of the MGMT DNA-repair gene has been linked to a favourable prognosis in de-novo malignant gliomas treated with alkylating agents. In patients with recurrent tumors after radio-/chemotherapy, it has been hypothesized that tumor progression might be correlated with[for full text, please go to the a.m. URL]