Role of IRE1 in glioma development – a preclinical study

G. Auf, S. Guérit, A. Jabouille, T. Gaiser, A. Bikfalvi & M. Moenner
Objective: Ischemia is associated with glioma development and locally induces an adaptive response which confers an enhanced survival and a more agressive behaviour to tumor cells. Hypoxia or glucose deprivation activate complex intracellular signaling referred to as the Unfolded Protein Response (UPR).[for full text, please go to the a.m. URL]