Inhibition of DNA damage repair by the Pyridinylfuranopyrimidine Inhibitor PI-103 sensitizes Glioblastoma cells for apoptosis

J. Kandenwein, M.A. Westhoff, K.M. Deabtin, G. Antoniadis, V. Braun & S. Fulda
Objective: Glioblastoma multiforme (GBM) are the most common primary brain tumors and among the deadliest cancers per se. The failure of conventional therapeutic approaches is – at least in part – believed to be due to aberrant activity of the PI3-Kinase/Akt initiated survival cascade,[for full text, please go to the a.m. URL]